多囊卵巢综合征患者家族疾病情况调查分析.docVIP

多囊卵巢综合征患者家族疾病情况调查分析 【摘要】目的调查多囊卵巢综合征(PCOS)患者家族疾病发生情况并进行分析,以期对PCOS家族疾病的预测和预防提供一定的理论依据。方法按PCOS诊断标准确立先证者核心家系73个，在先证者家乡选择正常人及其家系73个作为对照组。设计统一的调查量表，专人调查一、二级亲属的疾病史。结果PCOS组高血压、糖尿病、冠心病、精神分裂症及总的疾病发病数PCOS组均高于对照组，差异显著性。结论PCOS组的家系成员除高血压、糖尿病、冠心病患病率增高外，精神分裂症及总的心身疾病患病率也增加，说明心理因素的作用不容忽视。应及早地预测和预防。 【关键词】 多囊卵巢综合征； 家谱； 心血管疾病； 糖尿病 Investigation on family with polycystic ovary syndrome WANG Yurong, CAO Yunxia, ZHOU Ping, PAN Faming 1.Chaohu Vocational and Technical College, Chaohu 238000, China; 2.Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; 3.School of Public Health, Anhui Medical University, Hefei 230032, China 【Abstract】 Objective To provide some theoretical basis for forecasting and preventing of the diseases of PCOS family. Methods 73 PCOS probands with family history of PCOS were diagnosed according to the PCOS diagnostic criteria. Control groups included 73 healthy women whose sexual distinctions, age, marital status and homeland were similar to PCOS probands. All the patients were under the same questionnaire by the same investigator. All familial diseases had been investigated. Results There were a significant defference in incidence of cardiovascular disease, NIDDM, psychological disturbances and all psychosomatic disease between PCOS group and controls. Conclusions Cardiovascular disease and NIDDM has been found increased in PCOS family. psychological disturbances and all psychosomatic disease has been found increased in PCOS family, too. It is important to pay attention to the mental diseases so that they can be predicted and prevented. 【Key words】 Polycystic ovary syndrome; Pedigree; Cardiovascular diseases; Diabetes mellitus (Chin J Dis Control Prev 2008，12(1)：1113) 多囊卵巢综合征(polycystic ovary syndrome,PCOS)是育龄妇女常见的一种较为复杂的内分泌及糖代谢异常所致的病理状态，以雄激素过多及长期无排卵为特征，临床表现有月经紊乱、闭经、不孕、痤疮、多毛或肥胖等，其男性表现型为早秃。研究表明PCOS有导致动脉粥样硬化、高血压、Ⅱ型糖尿病等远期并发症的危险［1］。 近年来，国内外有学者开始调查PCOS家系成员的疾病发生情况，但调查的仅仅是目前认为和PCOS远期并发症有关的疾病，为了全面、系统地分析