aptamerconjugated_extracellular_nanovesicles_for_targeted_drug_delivery.cancer_res10.115800085472.can172880_资料6.Image.Marked.pdf

Author Manuscript Published OnlineFirst on December 7, 2017; DOI: 10.1158/0008-5472.CAN-17-2880 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Aptamer-conjugated extracellular nanovesicles for targeted drug delivery 1,2,† 3,4† 3 3 5 3 3 Yuan Wan , Lixue Wang , Chuandong Zhu , Qin Zheng , Guoxiang Wang , Jinlong Tong , Yuan Fang , Yiqiu Xia1,2, Gong Cheng1,2, Xia He4,*, and Si-Yang Zheng1,2,6,7,* 1Department of Biomedical Engineering, Micro and Nano Integrated Biosystem (MINIBio) Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802, USA 2Penn State Materials Research Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, USA 3 The Second Affiliated Hospital of Southeast University, Nanjing, Jiangsu 210028, China 4Jiangsu Cancer Hospital Jiangsu Institute of Cancer Research Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210009, China 5 Zetect Biomedical Company, Nanjing, Jiangsu 210028, China 6The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA 7Department of Electrical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA †Equal contribution *Corresponding author: Si-Yang. Zheng, N -238 Millennium Science Complex, Penn State University, University Park, PA 16802-6804, USA. Tel: +1 814-865-8090, Fax: +1 814-863-0490, Email: sxz10@ Xia He, Department of Radiation Oncology, Jiangsu Cancer Hospital Institute Affiliated to Nanjing Medical University, No. 42 Baiziting Road, Nanjing, Jiangsu 210009, China. Tel: +86 25-832-83565, Fax: +86-25-832-83565, Email: hexiabm@163.com Running Title: Preparation of cancer targeted extracellular nanovesi