微RNA-133和心肌肥厚钙调磷酸酯酶控制的相互抑制(英文)教材课程.pptVIP

Reciprocal Repression between MicroRNA-133 and Calcineurin Controls Cardiac Hypertrophy: A Novel Mechanism for Progressive Cardiac Hypertrophy De-Li Dong, Yan-Jie Lu, Bao-Feng Yang (董德利 吕延杰 杨宝峰) Department of Pharmacology Harbin Medical University, P.R.China Aug.20-22,2009.Dalian Background Calcineurin/NFAT pathway induces Cardiac Hypertrophy Calcineurin activation in cardiac hypertrophy Decreased miR-133 expression in cardiac hypertrophy Overexpression of miR-133 inhibits cardiac hypertrophy Inhibition of miR-133 induces cardiac hypertrophy Aug.20-22,2009.Dalian 1. Calcineurin