HPV感染的演变过程讲解课件.pptVIP

* 全自动宫颈细胞分析系统 细胞诊断技术的革新 显 微 镜 炎 症 正 常 癌前病变 癌 不同病理期宫颈细胞形态 已知hr-HPV感染子宫颈鳞状上皮基底旁层细胞，以基因附加体或插入整合形式存在和表达。从而导致宿主细胞基因不稳定，细胞表型改变和无限增生。 How induces HPV cervical dysplasia and cancer? HPV invades basal cells dysregulates etabolism. Dysplastic cellsappear Normally, only parabasal cells proliferate Dysplastic cells move up and reach surface After ?2-4 weeks Epithelial cells maturate move in 7-14 days to surface HPV HPV infection via wounds in epithelium CIN1 CIN2 CIN3 Jan Baak et al. 0 1 2 3 4 5 6 7 Months CIN-3 CIN-2 CIN-1 nrm/react hrHPV 80% of hrHPV infected women do not develop CIN