il1β对大鼠脑内单胺及其行为影响的研究-effects of il1β on monoamine and its behavior in rat brain.docx

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il1β对大鼠脑内单胺及其行为影响的研究-effects of il1β on monoamine and its behavior in rat brain.docx

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il1β对大鼠脑内单胺及其行为影响的研究-effects of il1β on monoamine and its behavior in rat brain

part1:Thetotalmotiveactivityofratswasdecreasedafteri.c.v.IL-1β.Activetimewasreduced(comparedwithcontrolgroup,P＜0.05，ANOVA).ThelevelofNAinthehypothalamuswassignificantincreased(comparedwithcontrolgroup,P＜0.05，ANOVA)andshowedatendencytoincreaseintheotherparts.TheactivityofMAO-Bincreasedsignificantlyinhippocampus,frontalcortex,striatum.part2:Theactivetimeandmotiondistance,exploratorybehaviorofratswerereducedafterrestraintstress(comparewithcontrolgroup,P＜0.05，ANOVA),andbehaviordepressionisappearedafterrestraintstress，injectioni.c.v.IL-1βcanreversetheeffect.theratsexposedtorestraintstresswerepretreatedwithIL-1rathelevelofNAinthehypothalamusandfrontalcortexwassignificantincreased,5-HTandDAlevelwerereducedrespectivelyinmidbrainandfrontalcortex(comparewithcontrolgroup,P＜0.05，ANOVA);pretreatedwithIL-1ra,theactivityofMAO-Ainfrontalcortex,striatum,midbrainandActivityofMAO-Binfrontalcortex,midbraindecreasedsignificantlyrespectively(comparewithcontrolgroup,P＜0.05，ANOVA).part3：Afterexposedtounpredictedmildstressorsfor12consecutivedays,besidesThetotalactivityofratsweredeclined,activitytimeandexploratorybehaviorwerereducedtoo,behaviordepressionisappeared;theconcentrationofmonoaminetransmitterandtheactivityMAOchangedsignificantly.howevertheeffectofbehavoirdepressionandTRPdecrease，5-HIAAincreaseinmidbraincausedbychronicstresswerereversedbyintracerebroventricular(i.c.v.)injectionofIL-1ra(comparewithcontrolgroup,P＜0.05，ANOVA);Intracerebroventricular(i.c.v.)injectionof.IL-1rareducetheactivityofMAO-BincontrolratsandactivityofMAO-Ainratsexposedtochronicstress.Conclusions:1.IL-1βinthebrainmayplayanimportantroleinthebehavioraldepressioninducedbystress.2.IL-1βmediatesbehavioraldepressionviaits’regulationofmonoaminetransmitterinspecialbrainareaafterstress.3.TheactivityofMAOisoneofthereasoninIL-1βinducedmonoamineandbehaviorchanges.Accordingtoaboveresult,IL-1βmediatesstressinducedbehaviordepressioninrats,whichprobablyduetothechangeofconcentrationofmonoamineandactivityofMAOinrats’brain.Keywords: