il1β il6 tnfα il17和il23在翼状胬肉中的表达及意义-expression and significance of il 1β il 6 tnf α il 17 and il 23 in pterygium.docx
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il1β il6 tnfα il17和il23在翼状胬肉中的表达及意义-expression and significance of il 1β il 6 tnf α il 17 and il 23 in pterygium
IL-1β、IL-6、TNF-α、IL-17和IL-23在翼状胬肉中的表达及意义英文摘要ExpressionandsignificanceofIL-1β,IL-6,TNF-α,IL-17andIL-23inpterygiumAbstractObjective:ToinvestigatetheexpressionofIL-1β,IL-6,TNF-α,IL-17andIL-23inpterygium.Method:Aprospectivecaseseriesstudyenrolled30pterygiumpatients(30eyes)fromSeptember2014toDecember2014inourhospital(14males,16females,aged40to76yearsold,average55.5yearsold,lessthan60years13cases,morethan60yearsold17cases).Thecontrolgroupincluded8normalconjunctivatissues(aged40to75yearsold,average54.75yearsold).Afterfixed,embedded,HEstained,immunohistochemicalmethodwasusedtodetecttheexpressionofIL-1β,IL-6,TNF-α,IL-17andIL-23inpterygiumandnormalconjunctivatissues,andtocomparetheexpressiondifferencesoftheseinflammatorycytokinesinpterygiumtissuesindifferentageandsexgroups.Results:IL-1β,IL-6,TNF-α,IL-17andIL-23wasmainlydistributedintheepithelialcellsofpterygiumandnormalconjunctivatissues.TheexpressionofIL-1β,IL-6,TNF-α,IL-17andIL-23inpterygiumgroupwassignificantlyhigherthanthatinnormalconjunctivalgroup(t=11.695,10.290,6.890,5.798,9.312,P0.05).ThereisnosignificantdifferencesintheexpressionofIL-1β,IL-6,TNF-α,IL-17,IL-23betweenlessthan60yearsoldgroupandmorethan60yearsoldgroups(t=0.907,0.963,1.119,0.878,1.373,P0.05).AndthereisnostatisticalsignificancedifferentialexpressionofIL-1β,IL-6,TNF-α,IL-17,IL-23betweenmalegroupandfemalegroup(t=0.419,1.049,1.137,0.100,0.488,P0.05).Conclusion:ThehighexpressionofIL-1β,IL-6,TNF-α,IL-17,IL-23inpterygiumsuggestedthat英文摘要IL-1β、IL-6、TNF-α、IL-17和IL-23在翼状胬肉中的表达及意义theinflammatorycytokinesmaybeinvolvedintheoccurrenceanddevelopmentofpterygium.NosignificantdifferenceintheexpressionofIL-1β,IL-6,TNF-α,IL-17,IL-23betweendifferentagegroupsandsexgroupsofpterygiumsuggestedthatageandsexmayhavenorelationwiththeexpressionofinflammationcytokinesinpterygium.Keywords:pterygium;IL-1;TNF-α;IL-6;IL-17;IL-23Writtenby:QinJian-yingSupervisedby:ZhangXiao-feng目录第一部分引言...........................................................................................................
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