强直性脊柱炎铁蛋白变化及相关性研究.docVIP

强直性脊柱炎铁蛋白变化及相关性研究 　　【摘要】 目的 观察强直性脊柱炎(ankylosingsp ondyiltis,AS )患者的铁蛋白的变化及其与病情活动指标的相关性。方法 检测40例活动期AS患者铁蛋白、各活动性指标(ESR、CRP)及免疫球蛋白(IgA、IgG、IgM),另设正常对照组30例并检测上述指标;分析40例活动期AS患者铁蛋白与活动性指标的相关性。结果 ①与正常对照组相比,活动期AS患者铁蛋白、ESR、CRP、IgG、IgA明显增高(P0.05);②铁蛋白与ESR、CRP明显正相关(P0.05)。结论 活动期AS患者出现了铁蛋白、IgA、IgG的升高,且铁蛋白的升高与ESR、CRP具有相关性,IgA、IgG的升高提示活动期AS患者存在免疫紊乱,提示铁蛋白可以作为反应AS疾病活动性的一项客观指标,其升高机制可能是由于炎症因子的释放导致的免疫紊乱。 　　【关键词】强直性脊柱炎;铁蛋白;疾病活动性 　　 　　The changes and correlation of ferritin in ankylosingsp ondyiltis patients 　　KONGMei,XINGChang-yong, WANG Ying. 　　Department of Clinical Laboratory,The fifth affiliated hospital of Sun Yat-Sen University,Guangdong,Zhuhai 519000,China 　　【Abstract】 Objective To observe the ankylosing spondylitis (ankylosing spondyiltis,AS) in patients with ferritin and its relationship with disease activity indicators of relevance.Methods 40 cases of active AS patients with ferritin,the activity indexs(ESR,CRP) and immunoglobulins (IgA,IgG,IgM),a separate control group of 30 patients and to detect those targets; analysis of 40 cases of active stage AS in patients with ferritin and its relationship with disease activity indicators of relevance. Results ①Compared with normal control group,with active AS patients with ferritin,ESR,CRP,IgG,IgA was significantly higher (P 0.05).② Ferritin and ESR,CRP was positively correlated (P 0.05). Conclusion AS patients with active stage of the ferritin,IgA,IgG increased,the elevated ferritin and with ESR,CRP are relevant,IgA,IgG elevated in active AS patients have prompted the immune disorder,suggesting that ferritin AS disease activity can serve as a reaction of an objective index,mechanism of the increase may be due to the release of inflammatory factors cause the immune disorder. 　　【Key words】 Ankylosing spondylitis;Ferritin;Disease activity 　　 　　强直性脊柱炎(ankylosingsp ondyiltis,AS)是一种原因不明的以中轴关节慢性非特异性炎症为主的全身性结??组织疾病,也是一种常见的慢性致残性风湿病,其患病率为0.3%左右,主要累及骶髂关节、脊柱和髋关节[1]。该病在炎症性关节炎中占第2位,可引起腰痛、晨僵、脊柱活动受限、驼背畸形、外周关节受累、肌腱端炎、足跟痛等关节症状以及前葡萄膜炎或虹膜炎、心