病理学精品课件：e04.pptVIP

Chapter 4. Inflammation Section 1. Introduction 一 . Definition: 1. Inflammation: a defensive reaction in living tissue with vascular system to injurious stimuli. 2. Reaction of BVs is the central link limiting and killing injured F eliminating and absorbing necrotic T 3. The inflammatory responses is closely interviewed with the process of repair 4. Significance (1). Beneficial : without inflammation Infections would go unchecked injured organs might remain permanent wound would never heal (2). Harmful : hypersensitive reactions to drugs, toxins fibrinous pericarditis →constrictive pericarditis fibrous repair → intestinal obstruction 二 . Causes and classification (一) Causes 1. Biologic factors:Bac,Virus ,fungi ,parasites →the most common 2. Chemical factors Exogenous : drugs, acid Endogenous : 3. Physical agents: trauma , burn 4. Tissue necrosis 5. Allergic reaction:GN , TB (二) Clinical types 1. Peracute inflammation (1) sudden onset, lasting for hours or a few days (2) lesion: degeneration, necrosis, exudation 2. Acute inflammation (1) relatively short duration, lasting for a few days (2) lesions: degeneration, necrosis, exudation: neutrophils infiltration 3. Chronic inflammation (1) lasting longer duration for a few months or years (2) Lesions proliferation LC ,PC, Monocyte infiltration 4. Subacute inflammation (1) between acute and chronic inflammation derived from acute inflammation 三 . Basic pathologic changes 1. Alteration: Degeneration ,necrosis of local tissue cells Parenchymal C cellular swelling fatty change coagulative , liquefactive necrosis Mesenchymal C mucoid change amyl