国产与进口头孢他啶治疗小儿细菌性下呼吸道感染成本-效果分析.docVIP

国产与进口头孢他啶治疗小儿细菌性下呼吸道感染成本-效果分析 　　[摘要] 目的 对国产与进口头孢他啶治疗小儿细菌性下呼吸道感染的成本-效果分析。 方法 90例细菌性下呼吸道感染患儿随机分为G组和J组各45例，G组给予国产头孢他啶，J组给予进口头孢他啶进行治疗。 结果 两组总有效率及细菌清除率差异无统计学意义（P0.05）；两组成本-效果比为4.18（G组）和11.01（J组），组间比较差异具统计学意义（P 　　[关键词] 头孢他啶；下呼吸道感染；小儿；成本-效果分析 　　[中图分类号] R725.6 [文献标识码] B [文章编号] 1673-9701（2012）02-0056-02 　　 　　Cost-effectiveness analysis of domestic and imported ceftazidime in the treatment of bacterial lower respiratory tract infections in children 　　TU Rongliang YU Chunqing 　　Department of Paediatrics, Xiaoshan Hospital of Hangzhou City in Zhejiang Province, Hangzhou 311251, China 　　[Abstract] Objective To do the cost-effectiveness analysis of domestic and imported Ceftazidime in the treatment of bacterial lower respiratory tract infections in children. Methods All of 90 children with bacterial lower respiratory tract infections were randomly divided into G group(45 cases) and J group(45 cases).G group treated by domestic ceftazidime and J group treated by imported ceftazidime. Results There were no significant difference of the effective rate and bacteria eradication rate between two groups (P0.05). The cost-effectiveness ratio of G group and J group were 4.18 and 11.01, there was significant difference between two groups(P＜0.05). When drug prices down 10%, there was significant difference between two groups(P＜0.05). Conclusion The cost-effectiveness ratio of domestic ceftazidime in the treatment of bacterial lower respiratory tract infections in children is better than imported ceftazidime. 　　[Key words] Ceftazidime; Lower respiratory tract infections; Children; Cost-effectiveness analysis 　　 　　下呼吸道感染是儿科常见感染性疾病之一，包括支气管炎、支气管肺炎和支气管异物伴感染等疾病[1]，病原体以细菌感染多见。头孢他啶为半合成的第三代头孢菌素，抗菌活力强，抗菌谱广，在小儿细菌性下呼吸道感染治疗中广泛使用。近年来我院呼吸内科应用头孢他啶治疗下呼吸道感染，疗效满意，本文从经济学角度出发，对我院2009年6月～2010年12月收治的90例应用头孢他啶治疗的小儿细菌性下呼吸道感染患儿进行成本-效果分析，旨在为临床安全、有效、经济用药提供参考。 　　 　　1 材料和方法 　　1.1 一般资料 　　选择2009年6月～2010年12月我院收治患儿，根据临床症状、体征、细菌学检查和胸部X线检查确诊为下呼吸道感染，所有患者48 h内未使用其他抗菌素治疗。排除严重心肝肾功能不全、青霉素过敏、血液系统疾病及携带本实验耐药菌的患儿。纳入患儿90