(核医学课件)08.甲状腺显像知识介绍.pptVIP

Thyroid Imaging Duan Dong Department of Nuclear Medicine The First Affiliated Hospital of Chongqing Medical University Classification and principle of thyroid imaging Imaging agents and their features, imaging methods Normal and abnormal imaging Clinical application of thyroid imaging Contents The first part Classification and principle of thyroid imaging The Classification of thyroid imaging ①Thyroid static imaging ②Thyroid dynamic imaging Principle of static thyroid imaging Administrating an agent(131I-NaI or 99mTcO4- ) which can be trapped and accumulated selectively by thyroid when entering the body of patients. Certain time after administration, Detecting the r-ray emitted by radionuclides in the thyroid with certain nuclear device,then we can obtain the image of thyroid(site,morphology,size,function). Trapped by thyroid 131I or 99mTc r r r r Imaging agents and their characteristics Iodine-131(131I): Long physical half-life(8.04d) β-rays occupy 90%,r-rays only occupy 10% of its emission The energy of principal r-ray is high(364 Kev) A relatively high irradiation dose to the thyroid and whole-body Easily obtained and with lower cost Mainly be used for detecting ectopic thyroid tissue and metastasis of thyroid carcinoma The scanning must be performed at least 24h after oral 131I Iodine-123(123I): It decays by electron capture with a r-photon (energy is 159 Kev, which is very suitable for imaging). Physical half-life is 13.27h High cost(produced by cyclotron) Technetium –99m(99mTc) It decays by pure r-rays(energy is 140 Kev) Short Physical half-life(6.02h) Easily obtained and lower cost Lower irradiation dose to the thyroid and whole-body Disadvantage is its non-specificity Methods of imaging 1).Asking the disease history and palpating the thyroid of patients before the examination. 2). Administration of radiopharmaceuticals(or imaging agents) Table 1 Comparision of two agents Static imaging is begin at certain time(30min or 24h