impact of anxiety on prefrontal cortex encoding of cognitive flexibility.焦虑影响前额叶皮层编码的认知灵活性.pdfVIP

Please cite this article in press as: Park J, Moghaddam B. Impact of anxiety on prefrontal cortex encoding of cognitive flexibility. Neuroscience (2016), /10.1016/j.neuroscience.2016.06.013 Neuroscience xxx (2016) xxx–xxx REVIEW IMPACT OF ANXIETY ON PREFRONTAL CORTEX ENCODING OF COGNITIVE FLEXIBILITY JUNCHOL PARK AND BITA MOGHADDAM * Animal electrophysiological studies: local field potentials 00 Department of Neuroscience, University of Pittsburgh, Impact of anxiety on cognitive flexibility 00 Human studies 00 Pittsburgh, PA, USA Animal studies: current state of the field 00 Animal studies: challenges for future research 00 Abstract—Anxiety often is studied as a stand-alone con- Concluding remarks 00 struct in laboratory models. But in the context of coping Acknowledgements 00 with real-life anxiety, its negative impacts extend beyond References 00 aversive feelings and involve disruptions in ongoing goal-directed behaviors and cognitive functioning. Critical examples of cognitive constructs affected by anxiety are cognitive flexibility and decision making. In particular, anxi- ety impedes the ability to shift flexibly between strategies in INTRODUCTION response to changes in task demands, as well as the ability to