腹腔镜手术对妇科恶性肿瘤患者腹膜il-1影响-effect of laparoscopic surgery on peritoneal il - 1 in gynecological malignant tumor patients.docxVIP

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腹腔镜手术对妇科恶性肿瘤患者腹膜il-1影响-effect of laparoscopic surgery on peritoneal il - 1 in gynecological malignant tumor patients.docx

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腹腔镜手术对妇科恶性肿瘤患者腹膜il-1影响-effect of laparoscopic surgery on peritoneal il - 1 in gynecological malignant tumor patients

EFFECT OF LAPAROSCOPIC SURGERY ON EXPRESSION OF IL-1 IN PERITONEUM OF PATIENTS WITH GYNENOLOGICAL MALIGNANCYABSTRACTObjectToevaluatetheeffectofcarbondioxidepneumoperitoneumon expression of IL-1 in peritoneum of patients with gynecological malignancy. Materials and MethodsSixty wowen with gynecological tumor were divided into four groups:10 patients in myoma laparoscopy group; 10 patients in myoma laparotomy group.25 patients in cancer laparoscopy group;15 patients in cancer laparotomy group.The expression of IL-1 of peritoneal mesothelial cells were measured at various time points (beginning of operation, 30 min and 60min intraoperatively) and various positions (near or far away from incision) through immunohistochemistry.ResultsAt 0m ,the expression of IL-1 in maligment group was higher than that inbenign group(P0.05).As surgery time going,the expression of IL-1 in malignant laparoscopy group: 30m0m,60m30m(P0.05),which in benign laparoscopy group:60m0m (P0.05).In maligment laparotomy group,IL-1 only slowly decreased at 60m and its expression degree were higher than that in laparoscopy group.In benign laparotomy group,IL-1 had no significant difference as surgery time going .There was no comparation difference in typeof maligment tumor（P0.05）. There was no significant difference of theexpression of IL-1 between peritoneum at incision and far away from incision (P0.05).ConclusionsCarbon dioxide pneumoperitoneum used in laparoscopic surgery significantly decreased the expression of IL-1 of peritoneal mesothelial cells and it decreased as surgery time going .It suggested that carbon dioxide pneumoperitoneum may depress the defence and immunity of the peritoneum,which could increase the risk of malignant tumor spread after laparoscopic surgery. In maligment open surgery,the expression change of IL-1 was slighter and slower than that in laparoscopic surgery.KEY WORDScarbon dioxide,laparoscopy, IL-1, peritoneum,malignant tumor上海交通大学学位论文原创性声明本人郑重声明：所呈交的学位论文，是本人在导师的指导下，独立进