细胞信号传导-精美英文-cellularsignaltransductionpathway.ppt

cellular signal transduction pathway G protein-mediated signal transduction Tyrosine protein kinase-mediated signal transduction Guanylate cyclase signal transduction pathway Nuclear receptor-mediated signal transduction Three subunits The sequence of events by which a hormone activates cAMP signaling: 1. Initially Ga has bound GDP, and αβ γ subunits are complexed together. 2. Hormone binding to a 7-helix receptor (GPCR) causes a conformational change in the receptor that is transmitted to the G protein. The nucleotide-binding site on Ga becomes more accessible to the cytosol, where [G