神经变性及遗传疾病-print.ppt

* * * * * * Figure 1. Schematic Illustration of the Three Primary End Points of the Study. The three primary end points, which had to be met in a hierarchical fashion to declare positive results, are shown. The green arrows indicate the first end point: the superiority of early-start treatment versus placebo with respect to the estimate of the rate of change from baseline in the total Unified Parkinson’s Disease Rating Scale (UPDRS) score between weeks 12 and 36. The red arrow indicates the second end point: the superiority of early-start treatment versus delayed-start treatment with respect to the estimate of change in the total UPDRS score between baseline and week 72. The blue arrows indicate the third end point: the noninferiority of early-start treatment as compared with delayed- start treatment with respect to the estimated rate of change from baseline in the slope for the total UPDRS score between weeks 48 and 72. The dashed yellow line indicates placebo, and the solid blue lines indicate rasagiline. * * * * * * * 对左旋多巴5年以上有效的。才能做手术。5年以上还有叠加的10% * While the majority of cases meet classification criteria for minor depression, only 4 to 6% of PD patients suffer from major depression according to DSMIV criteria, with higher rates in patients with associated dementia. This finding indicates that depression in PD is mostly of mild to moderate severity. Agoraphobia 广场恐怖症 * hedonistic - 享乐主义  * Note the diffuse hyperintensity (yellow spot)corresponding to increased Trace(D) valuein the putamen of the MSA-P patient (a), most prominently in the posterior putamen. Regions of interest are placed in the putamen, which is divided into two halves along its lateral border. The colors blue, green, yellow, red and black represent descending Trace(D) values. Reproduced with permission from Seppi et al., “Topography of putaminal degeneration in multiple system atrophy: a diffusion magnetic resonance study.” Mov. Disord. 2006, Wiley-Blackwell[159] * Textbook of Primary Car