rhoa分子在登革2型病毒感染过程中的作用分析-analysis of rhoa molecules role in dengue type 2 virus infection.docxVIP

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rhoa分子在登革2型病毒感染过程中的作用分析-analysis of rhoa molecules role in dengue type 2 virus infection.docx

rhoa分子在登革2型病毒感染过程中的作用分析-analysis of rhoa molecules role in dengue type 2 virus infection

RoleofRhoAindenguevirusserotype2infectionAbstractDenguevirus(DV)belongstothefamilyFlavivirusandtherearefourserotypes(DV1-4).Theycauseamild-to-debilitatingfebrileillness(classicaldenguefever,DF)orlife-threateningsyndrome(denguehaemorrhagicfever/dengueshocksyndrome,DHF/DSS).Annuallytherearemillionsofinfectionsandattensofthousandsofdeaths.TheinfectingDVisabletoproduceanacutefebrilesyndromecharacterizedbyclinicallysignificantvascularpermeability(DHF/DSS).Anestimated500000casesofDHFrequirehospitalisationeachyear,andupto50%maydieifnotproperlydiagnosedandtreated.However,nocurrentlylicensedvaccinesora

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rhoa分子在登革2型病毒感染过程中的作用分析-analysis of rhoa molecules role in dengue type 2 virus infection.docxVIP