高脂血症治疗目标：高密度脂蛋白课件.pptVIP

HDL as a Therapeutic TargetDaniel J. Rader, M.D. Low HDL-C is an Independent Predictor of CHD Risk Even When LDL-C is Low Low HDL-C was redefined as 40 mg/dL Is HDL-C Simply a Marker of Increased Cardiovascular Risk? Smoke Are sedentary Are obese Are insulin resistant or diabetic Have hypertriglyceridemia Have chronic inflammatory disorders Production of Apo A-I by Liver and Intestine Increased Apo A-I Production is Antiatherogenic in Animals Reduced initiation and progression of atherosclerosis in transgenic mice and rabbits Regression of pre-existing atherosclerosis in animals HDL Meta