健脾运湿法对单纯性肥胖糖调节受损脾虚不运证患者血清胰高血糖素样肽-、抵抗素、胰岛素水平影响.docx

The Influence of Strengthen the Spleen, Dry, and Transform Phlegmon the Glucagon-like- Peptide-1(GLP-1) ,Resistin and InsulinofImpaired Glucose Regulation (IGR) 0besity Patients Who SpleenAstheniawith DampnessSpeciality：Diabetes amp; Endocrinology of Integrated Traditional Chinese and ModernMedicineAuthor：Yu ZhengYu ZhengTutor：Prof．Feng Jianhua Prof．Feng JianhuaAbstractThere are two parts in this thesis： Reference review of obesity，and experimentalstudy on the prevention and treatment for impaired glucose regulation (IGR) obesitypatients of spleen asthenia who can’t dry and transform dampness by strengthen the spleen,dries, and transforms phlegm.Reference review:This essay reviewed from the advances of such fields asfollowed： reference review of chinese medicine and modern medicine researchs.We had asystematic discussions from the pathogenesis theory, syndrome differentiation，and clinicaland experimental study for obesity with Chinese medicine and modern medicine.Objective:To explor the influence of strengthen the spleen, dry, and transform plegmon the glucagon-like- peptide-1(GLP-1) ,resistin and insulinofIGR obesity patientswho spleen asthenia with dmpness，and improving insulin resistance and isletβcellfunction by strengthen the spleen, dry, and transform phlegm. We investigated theinfluence of strengthen the spleen, dry, and transform phlegm，on the glucagon-likepeptide-1 (GLP-1) ,resistin and insulin,signaling pathway for IGRof obesity patientswho spleen astheniawith dmpness，in order to supply the basic theory and experimentaldata for chinese medicine．Methods：60 cases for IGR of obesity patients of spleen astheniawith dmpness subjects were random selected. Every one took use of 250 mg three timesevery day for 12 weeks. And the study group took use ofmodified Ginseng、Poria andWhite Atractylodes Decoction. Record the number of weight,waist circumference(WC),hip circumference(HC),midupper arm circumference (MAC), subscapular skin foldthickness(SSF) .In addition,BCA-