,-戊二胺的细菌合成及应用.doc

1,5-戊二胺的细菌合成及应用 Engineering 3 (2017) 308–317 Contents lists available at ScienceDirect Engineering j o u r n a l h o m e p a g e : w w w . e l s e v i e r. c o m / l o c a t e / e n g Research Green Chemical Engineering—Review Advances in Cadaverine Bacterial Production and Its Applications Weichao Ma a,b,c, Kequan Chen a,b,*, Yan Li a,b, Ning Hao a,b, Xin Wang a,b, Pingkai Ouyang a,b a b c State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, China College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China College of Bioengineering and Biotechnology, Tianshui Normal University, Tianshui 741001, China a r t i c l e i n f o a b s t r a c t Cadaverine, a natural polyamine with multiple bioactivities that is widely distributed in prokaryotes and eukaryotes, is becoming an important industrial chemical. Cadaverine exhibits broad prospects for various applications, especially as an important monomer for bio-based polyamides. Cadaverine-based polyamide PA?5X has broad application prospects owing to its environmentally friendly characteristics and exceptional performance in water absorption and dimensional stability. In this review, we summarize recent findings on the biosynthesis, metabolism, and physiological function of cadaverine in bacteria, with a focus on the regulatory mechanism of cadaverine synthesis in Escherichia coli (E. coli). We also describe recent developments in bacterial production of cadaverine by direct fermentation and whole-cell bioconversion, and recent approaches for the separation and purification of cadaverine. In addition, we present an overview of the application of cadaverine in the synthesis of completely bio-based polyamides. Finally, we provide an outlook and suggest future developments to advance the production of cadaverine from renewable resources. ? 2017 THE AUTHORS. Published by Elsevier LTD on behalf of the Chinese Academy of Enginee