scaav9higf1逆轴突靶向运动神经元干预als小鼠模型作用及机制研究-study on the effect and mechanism of sca av 9 higf 1 inverse axonal targeting motor neurons interfering with als mouse model.docx

万方数据 万方数据 目 录 中文摘要··········································································································· 1 英文摘要··········································································································· 6 英文缩写··········································································································12 研究论文 ScAAV9-hIGF1 逆轴突靶向运动神经元干预 ALS 小鼠模型作用 及机制研究 引言··········································································································14 第一部分 ScAAV9-hIGF1 逆轴突靶向转染运动神经元的理论和实践 前言 16 材料与方法······························································································17 结果··········································································································27 附图··········································································································28 讨论··········································································································31 小结··········································································································33 参考文献··································································································34 第二部分 肌肉注射 scAAV9-hIGF1 干预 ALS 小鼠模型疗效观察 前言 37 材料与方法······························································································38 结果··········································································································45 附图··········································································································47 讨论··········································································································52 小结··········································································································54 参考文献··································································································55 第三部分 ScAAV9-hIGF1 对 ALS 小鼠模型保护机制研究 前言 58 材料与方法····································