氟西汀和多虑平治疗糖尿病伴情绪障碍的对照研.docVIP

氟西汀和多虑平治疗糖尿病伴情绪障碍的对照研 【摘要】 目的 探讨氟西汀对伴抑郁、焦虑的糖尿病患者的疗效及对糖代谢的影响。方法 105例伴抑郁、焦虑症状的糖尿病患者被随机分为氟西汀组、多虑平组和对照组，氟西汀组在维持原糖尿病治疗方案同时加用氟西汀每日1次，每次10 mg，口服;多虑平组维持原糖尿病治疗方案，同时加用多虑平片，每日中、晚各服25 mg，对照组维持原治疗方案，不应用抗抑郁剂， 疗程4周，采用Zung抑郁自评量表(SDS)与Zung焦虑自评量表(SAS)评定焦虑症状及改善情况;检测空腹血糖(FPG)、餐后2 h血糖(2hPG)和糖化血红蛋白(HbAIC)评价糖代谢情况。结果 治疗4周后，氟西汀组和多虑平组SDS、SAS评分较治疗前降低(Plt;0.05)，FPG、HbAIC水平较治疗前降低，有统计学意义(Plt;0.05)，氟西汀组较多虑平组SAS、SDS评分降低更明显，存在统计学意义(Plt;0.05)，2组间比较FPG、2hPG、HbAIC下降无显著性差异(Pgt;0.05);对照组治疗前后SAS、SDS评分、FPG、2hPG、HbAIC无统计学差异(Pgt;0.05)。结论 氟西汀、多虑平明显改善糖尿病患者的抑郁焦虑症状，有助于控制血糖，氟西汀较多虑平副作用少。 　　【关键词】 氟西汀 多虑平 糖尿病 抑郁 焦虑 　　Control study of efficacy of fluoxetine and doxepin on diabetic with mood disorder CHEN Huimin1,ZHAO Zheng1,JIANG Yuhui1,et al (Department of Psychology,the Second Affiliated Hospital of Xinxiang Medical College,Xinxiang 453003,China) 　　Abstract: Objective To explore the effect of fluoxetine on diabetes with depression and anxiety,and the influence of glycometabolism.Methods One hundred and five diabetic with anxiety and depression were divided into 3 groups(fluoxetine group,doxepine group,and control group) randomly.Three groups retained original treatment plan,with fluoxetine group receiving fluoxetine 10 mg by mouth，once a day,and doxepine group receiving doxepine 25 mg by mouth,serving at noon and night every day.control group receiving no thymoleptics.The therapy cycle was 4 weeks.Anxious symptom and its improved condition were evaluated by selfrating depressive scale(SDS) and selfrating anxious scale (SAS).Detecting fasting plasma glucose(FPG)，2 h′s postprandial blood glucose(2hPG) and glycosylated hemoglobin(HbAIC) to estimate the condition of glycometabolism.Results After 4 weeks′ treatment,the scores of SDS and SAS,the level of FPG and HbAIC decreased significantly in fluoxetine group and doxepine group (Plt;0.05),but the scores of SDS and SAS in fluoxetine group decreased more significantly than that in doxepine group(Plt;0.05).There was no obviously difference in FPG、2hPG、HbAI