associations between circadian activity rhythms and functional brain abnormalities among euthymic bipolar patients a preliminary study文档.pdfVIP

NIH Public Access Author Manuscript J Affect Disord . Author manuscript; available in PMC 2015 August 01. N Published in final edited form as: I H J Affect Disord . 2014 August ; 164: 101–106. doi:10.1016/j.jad.2014.04.034. - P A A u Associations between Circadian Activity Rhythms and t h o r Functional Brain Abnormalities among Euthymic Bipolar M a Patients: A Preliminary Study n u s c Benjamin S. McKennaa,b,*, Sean P. A. Drummondb,c,d, and Lisa T. Eylera,b r i p a t VA San Diego Healthcare System, VISN-22 Mental Illness Research, Education, and Clinical Center, San Diego, CA 92161 bUniversity of California, San Diego, Department of Psychiatry, La Jolla, CA 92161 cVA San Diego Healthcare System, Psychology Service, San Diego, CA 92161 d N VA San Diego Healthcare System, Center for Excellence in Stress and Mental Health, San I H Diego, CA 92161 - P A Abstract A u t h Background—Working memory and underlying functional brain deficits have been observed in o r euthymic bipolar disorder (BD) patients, though there is heterogeneity in the degree of deficits. M Sleep/circadian rhythm abnormalities are thought to be a core component of BD and may explain a n some of the heterogeneity in functional abnormalities. This preliminary study examined u s associations between sleep/circadian rhythm abnormalities and functional magnetic resonance c r i p imaging (fMRI) brain response on a working memory task among BD patients. t Methods—Fourteen euthymic medicated BD patients w