NEONATAL SEIZURES生儿惊厥PPT.pptVIP

Major Etiologies of Neonatal Seizures in Relation to Time of Seizure Onset and Relative Frequency TIME OF ONSET* RELATIVE FREQUENCY? 0-3 DAYS 3DAYS PREMATURE FULL TERM Hypoxic-ischemic + +++ +++ encephalopathy Intracranial + + ++ + hemorrhage? Intracranial infection + + ++ ++ Developmental + + ++ ++ defects Hypoglycemia + + + Hypocalcaemia + + + + Other metabolic + + Epileptic syndromes + + + * Inborn Errors of Metabolism Associated With Neonatal Seizures Conditions That Have a Specific Treatment Pyridoxine (B6) dependency Folinic acid-responsive seizures Glucose transporter defect Creatine deficiency Other Conditions Nonketotic hyperglycinemia Sulfite oxidase deficiency Molybdenum cofactor deficiency (combined deficiency) Carbohydrate-deficient glycoprotein disorder Lactic acid disorders Mitochondrial disorders Maple syrup urine disease Isovaleric acidemia (sweaty feet, cheesy odor) * Inborn Errors of Metabolism Associated With Neonatal Seizures Other conditions Isovaleric acidemia (sweaty feet, cheesy odor) 3-methylcrotonyl-CoA carbosylase deficiency Propionic acidemia Mevalonic aciduria Urea cycle defects Hyperornithemia-Hyperammonemia-Homocitrullinuria (HHH) syndrome Neonatal glutaric aciduria type ll Biotin deficiencies, holocarboxylase synthetase deficiency Fructose 1,6-diphosphatase deficiency Hereditary Fructose intolerance Menkes disease (trichop