冠状动脉扩张症患者胰岛素水平及其与MMP9.docVIP

冠状动脉扩张症患者胰岛素水平及其与MMP9/TIMP1比例的关系 唐振旺谭小进 [1]?湖南省祁东县人民医院，湖南衡阳421600 [2] 南华大学附属第一医院 基金项目：湖南省卫生厅科研基金资助项目（B2012-049） 摘要: 目的 冠状动脉扩张症(CAE)患者血浆胰岛素水平及其与基质金属蛋白酶-9MMP-9)/基质金属蛋白酶组织抑制因子1(TIMP1)比例失衡的关系。方法 选择本院行冠脉造影患者，根据造影结果分为冠脉扩张组冠脉正常组40例18例，单纯冠脉扩张22例冠脉扩张伴少量斑块组，，冠脉正常不伴狭窄或斑块形成组，，冠脉无明显狭窄但有散在斑块检测血浆胰岛素、MMP-9和TIMP1水平，的危险因素结果 与冠脉正常组相比，冠脉扩张组患者的血浆胰岛素、MMP-9水平及MMP-9/TIMP1比值高TIMP1水平低P0.05)。亚组分析显示血浆胰岛素、MMP-9水平及MMP-9/TIMP1比值A1组组组(P均0.05)，TIMP1水平为 B1组组组(P 0.05)。相关性分析结果显示血浆胰岛素水平与MMP-9呈正相关r=0.572，P0.01)，与TIMP1呈负相关r=-0.568， P0.01；MMP-9与TIMP1呈负相关r=-0.468，P0.01血浆胰岛素及MMP-9/TIMP1是的危险因素(P 0.05)。结论 患者胰岛素水平较高，可能通过调节MMP-9和TIMP1水平参与。 关键词：冠状动脉扩张，胰岛素，基质金属蛋白酶-9，基质金属蛋白酶组织抑制因子1 Clinical investigation of plasma insulin level and its correlation to the ratio of MMP-9/TIMP1 in patients with coronary artery ectasia PENGXi-Yi,CHEN-Zhong,TANGZhen-Wang,TANXiao-Jin (1:TheHunan?CountyinQidongprovincepeoples?Hospital,Hengyang?421001;2:Department?of?Cardiovascular?Medicine,?First?Affiliated?Hospital,?Nanhua?University,?Hengyang?421001,?Hunan,?China) Abstract Objective To analyze the plasma level of insulin, matrix metalloproteinase -9 (MMP-9) and tissue inhibitor of metalloproteinases 1(TIMP1) in patients with coronary artery ectasia (CAE), and to explore the correlation of plasma insulin, MMP-9 and TIMP1. Methods The 80 cases undergoing coronary angiography (CAG) in our hospital were collected and divided into two groups according to the result of CAG, which were the CAE group and the normal group. Each group had 40 cases. And each group was divided into two sub-groups, which were A1 sub-group (18 cases, simple CAE), A2 sub-group (22 cases, CAE combined little plaque), B1 sub-group (25 cases, coronary artery completely normal), B2 sub-group (15 cases, simple little plaque). The plasma levels of insulin, MMP-9 and TIMP1 were detected and compared among all groups and sub-groups. The correlations of plasma insulin, MMP-9 and TIMP1 were analyzed. The risk factors of CAE were analyzed by multiple Logistic regression analys