造血干细胞移植后的感染 黄晓军幻灯片.pptVIP

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Various antifungal agents target different parts of fungal cells as illustrated here. The antifungal agents in yellow are those currently approved by the FDA; those in white are in varying stages of development. The polyenes, amphotericin B, its lipid formulations, and nystatin interfere with membrane function. They are derived from Streptomyces species, are fungicidal, and have a broader range of action than other types of antifungal agents. They bind to membrane sterols causing increased membrane leakage and cell death. Those that