glut1 vegf在胰腺癌中表达及意义-expression and significance of glut 1 vegf in pancreatic cancer.docx

Expression and significance of VEGF and Glut-1 in human pancreatic carcinomaAbstractPrimary pancreatic carcinoma(PPC) as a common malignant tumor in alimentary is a clinical symptom to hide ,it make progress quickly, and its prognosis is very bad and the existence rate of PPC is very low.Its biology characteristics: easily invasion nerve and blood vessel, the rate of lymphometastasis is high, and the anatomy position of PPC is deep, and lack the particularity toumor marker and the clinical manifestations in early grade, etc.As the same time, the postoperative recurrence or metastasis of PPC is easy occurrence. 75% of the accurate clinical diagnosis of PPC or more is already belong to the medium or later period, the surgical operation excision rate of PPC is low, and its not sensitive to the chemotherapy and radiotherapy. The existence rate of 5 years is still 5%.After the comprehensive treatment , it is predicting the tumor to relapse and metastasis, evaluating the prognosis of PPC that is a key place to raise the existence rate.To solve this problem must build up the particularity index that can predict the postoperative recurrence or metastasis and further evaluate the treatment result.Currently those original studies are concentrat on early diagnosis and the therapy, but not studies to evaluate its prognosis through finding the tumor marker , the research on recurrence or metastasis of PPC is less .At home and abroad currently ,its research still just the start stage, the beginning see the clues.Glucose transporter protein which mediated glucose uptaked is the main carrier. So far there have been eight kinds of glucose transporter protein (glucouse transporters)identified (Glut1-5 and Glut7-9). Glut-1 is the transit body which is the most widely known .But in normal tissue ,Glut-1 expression confined primarily to red blood cells , the brain, eyes, nerves and placenta.The expression levels of Glut-1 are often very low in other tissue cells. Glut-1 which has been i