ge对嗅球损毁抑郁大鼠模型抗抑郁作用分析-effect of ge on depression in rats with olfactory bulb lesion.docx

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2018-06-04 发布于上海
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ge对嗅球损毁抑郁大鼠模型抗抑郁作用分析-effect of ge on depression in rats with olfactory bulb lesion.docx

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ge对嗅球损毁抑郁大鼠模型抗抑郁作用分析-effect of ge on depression in rats with olfactory bulb lesion

ABSTRACTObjective:ToinvestigatetheantidepressanteffectsandmechanismofGEby therapeuticdepressantmodelwithratsandmice.Methods:OlfactoryBulb damagetyperatswasadopted.Withtheindicatorsincludingdivingplatformpassiveevasionexperiment,evadesthedarkpassiveevasionexperiment, massacrestheexperiment,syrupconsumption,bloodserumcortisone, monoaminergicneurotransmitters,SODandMDA,weinvestigatedtheeffectsof GE on antidepression.Results: 1.In diving platform passive evasionexperiment,13.33mg/kgGEdosegroupreduceobviouslythewrongtimesoftrainingandtesting(P0.05）,13.33、6.67、3.33mg/kgGEdosegroupsprolong significantlythelatencyofmistakesoftesting(P0.05).2.Inevadesthedark passiveevasionexperiment,13.33mg/kgGEdosegroupreducegreatlythe wrongtimesoftrainingandtesting(P0.05),prolongsignificantlythelatencyof mistakesoftraining(P0.01）,notlyprolongthelatencyofmistakesof testing(P0.001）.6.67mg/kgGEdosegroupprolongobviouslythelatencyof mistakesoftraining(P0.05）;prolongobviouslythelatencyofmistakesof testing(P0.01）3.Onthe7thdayofadministration,thesrupconsumption(sc)and sc/100ghavenosignificantlydiffrence(P0.05);Onthe14thday,thescandsc/100gofmodelsetfalldownnotlycomparedwithpseudo-operation group(P0.05）.Comparedwithmodelgroup,13.33mg/kggGEdosegroupcan increasethescandsc/100g(P0.05）obviously,6.67mg/kgGEdosegroup increasethescnotly(P0.05）.4.Thescoresofmassacrestheexperimentof OlfactoryBulbdamagetyperatsraisegreatly(P0.05),13.33、6.67mg/kgGE dosegroupscanreducethescoresignificantly(P0.001,P0.05）;SOD、MDAandbloodserumcortisoneofOBratsrisingobviouslyornotly(P0.05,P0.001),、6.67、3.33mg/kgGEdosegroupscanincreaseSODinbrainofrats(P0.05）,canreduceMDAinbrainofratssignificantlyorgreatly;cannotlyorobviouslydecreaseblood serumcortisoneof OBrats(P0.01,P0.05）.Itshow thattheantidepressivemechanismofGEisrelatedwithanti-oxidationinbraintissueandinhibitinghyperfunctionwithHPAcausedbyresponding stimulus,reducingexcretionofglucocorticoid.5.NAand5-HTinprefrontalcortexandhippocampusofOBratsfallnotly(P0.001),13.33、6.67G