复方鳖甲软肝片联合核苷类药物对乙肝肝硬化患者血清pdgf-bb影响及相关研究-effect of compound biejia ruangan tablets combined with nucleoside drugs on serum pdgf - bb in patients with hepatitis b cirrhosis and related research.docx

个长期的过程。关键词复方鳖甲软肝片；血小板衍生生长因子-BB；透明质酸；核苷类药物；乙肝肝硬化IICompoundBiejiaruangantabletscombinednucleosidedrugtreatmentofhepatitisBcirrhosisonserumPDGF-BBinfluenceandrelatedresearchABSTRACTObjectiveToexploretheserologicaldiagnosticmarkerofliverfibrosis,Clearsignificanceaboutplatelet-derivedgrowthfactor-BBofseruminthediagnosisofliverfibrosis,ExploretheCompoundBiejiaruanganpieceintheanti-liverfibrosismayexistinmechanismofaction,AndobservetheeffectofcompoundBiejiaruangantabletsandnucleosidedrugtreatment.MethodsMarch2010Mayto2011inourdepartment(GeneralHospitalofNingxiaMedicalDiseaseDivision)regularlyreviewtheout-patienthepatitisBpatientswithcirrhosisandhospitalizationinpatientswithlivercirrhosis62casesofinfection,wererandomlydividedintotwogroups(A,B)+nucleosidedrugs,anti-virus,groupAforthetreatmentof31cases,togivecompoundBiejiaruanganpiece,thecourseofthediseasebasedonelevatedliveraminotransferaselevelsappropriatetogivebicyclolreducingenzymetreatment;groupBforthecontrolgroup31wastreatedwithnucleosidedrugs,anti-virus,reducingenzymetreatmentbicyclolandotherappropriategiventhecourseofthediseasebasedonelevatedlivertransaminaselevels.Treatmentlastedsixmonths.Andtoreceiveoutpatienthealthypersonsserum31casesofgroupCascontrolgroup.ObserveandrecordtheserumofPDGF-BB,andhyaluronicacid(HA),laminin(LN),collagentypeIV(IV-C)levelsandotherindicatorsbeforeandaftertreatment.ResultsWereincludedforthesubjectsofatotalof93casesinmind,groupA31cases,31casesofGroupB,healthblankcontrolgroupof31cases.SerumPDGF-BBandHA,LN,Ⅳ-CchangeingroupA,B,beforeandaftertreatmentwerestatisticallysignificantdifferences(P0.05).GroupAserum,PDGF-BBandHA,LN,Ⅳ-Cbeforeandaftertreatment,changesinlevelsthaningroupBthelevelofchangeismoresignificant,andthereisasignificantdifference(P0.05).GroupAandgroupBthetreatmentofportalveinandspleenthicknessvariationthanbeforetreatment,nosignificantdifference(P0.05).AandPDGF-BB,Bgroups62casesofhepatitisBpatientswithcirrhosisbeforetreatmentserumHA,LN,Ⅳ-C,thereisacertaincorrelation(P0.05).Conclusion