原发性高血压患者血管舒张功能 ca-imt与lvmi的关系-relationship between vasodilation function ca - imt and lvmi in patients with essential hypertension.docxVIP

(7.20± 4.72)%, P0.05 ] , TA-EDD[ (8.76± 6.69)% vs (6.99± 6.62)%, P0.05 ] ,BA-EID[ (16.48± 9.71)% vs (12.39± 6.23)%, P0.01] and TA-EID[ (17.19± 11.92)%vs ( 12.51± 9.44)%, P0.01] were decreased significantly; while CA-IMT(mm), LVMI and LVM/H2.7(g/m2.7) were increased significantly( 0.760± 0.269 vs 0.921± 0.227,94.41± 15.06 vs 138.02± 21.65, 42.06± 7.22 vs 61.91± 10.77 respectively; all P 0.01).Stepwise multiple regression analysis showed that no matter whether LVH existed or not, EDD and EID from the same target artery influenced each other. Age was an influencing factor for BA-EID, CA-IMT and LVMI; CA-IMT an influencing factor for BA-EDD, BA-EID and LVMI.When patients getting older, TA-EDD, BA- EID and TA-EID gradually decreased; while CA-IMT, LVMI and LVM/H2.7 gradually increased. BA-EDD was an influencing factor for CA-IMT and LVMI.In patients with thicken CA-IMT (CA- IMT=1.0 mm), EDD and EID from the two target arteries decreased; while LVMI and LVM/H2.7 increased.No matter what patients’ ages were, EDD and EID from the same target arteryinfluenced each other, and CA-IMT was always associated with blood pressure.No matter whether thicken CA-IMT existed or not, EDD and EID from the same target artery influenced each other, and there was always an association between BA-EID and TA-EID.Conclusion:Age is an influencing factor for vasodilatation, CA-IMT and LVMI. There are interactions among vasodilatation, CA-IMT and LVMI. More intensive treatment is needed to improve the vasodilatation in EH patients with LVH or thicken CA-IMT. The improvement of the vasodilatation could protect patients against CA-IMT thickening and left ventricular hypertrophy.There exists an interaction between EDD and EID. When EDD is impaired, EID is also decreased in the meantime.Key Words :Essential hypertension, Endothelium-dependent dilation, Endothelium- independent dilation, Intima media thickness of carotid artery, Left ventricular mass index.英文缩略词表 英文缩写 英文全称 中文全称 ApoA1 ApoB A