Pd-催化硫代酰胺化合物的α-芳基化反映.pdf

Abstract Thioamides are and blockswitll uniquesignificantsyntheticbuilding sulfur, a-carbonthree are usedin centers，which nitrogen,and adjacentnucleophilic widely the of wellas a of synthesis molecules，as manyimportant buildingvariety are usedascarbon for heterocycliccompounds．However,theyrarely nucleophiles C-C reactions．Thismasterthesisfocusedonthe transition-metal-catalyzed coupling of the Pd-catalyzeda—arylationthioamides，providingcorrespondinga-arylated thioamidesinmoderate to undermildreactionconditions．Thecurrent goodyields work includesthe three followingparts： 1．Aseriesofthioamide were thereactionofamides compounds preparedby andLawessonatrefluxin THF． reagent reactionconditionswereobtainedforthe of 2．Optimal Pd-catalyzeda-arylation thioamidesdetailed ofreaction by investigation parameters includingpalladium source，solvent，reaction base． temperature，ligand，catalystloading，and 3． Substrateforthe ofthioamideswas underthe scope 0【-arylation investigated conditions． optimized Key