小剂量紫杉醇联合顺铂在宫颈癌根治性放疗中应用.docVIP

小剂量紫杉醇联合顺铂在宫颈癌根治性放疗中应用 　　[摘要] 目的 探讨小剂量紫杉醇、顺铂联合放疗对Ⅱa～Ⅲb期宫颈癌的疗效及副反应。 方法 将65例宫颈癌患者分为TP1组和TP2组，TP1组：紫杉醇60 mg/m2，顺铂20 mg/m2，每8～10天重复。TP2组：紫杉醇135 mg/m2，顺铂60 mg/m2，化疗间隔21 d。同步行根治性放射治疗，比较其近期疗效及副反应。 结果 ①两组有效率相当，皆为100%；②TP1组总治疗时间明显短于TP2组（P ＜ 0.05）；③不良反应主要为血液毒性、消化道反应，TP1组发生严重骨髓抑制少于TP2组（P ＜ 0.05）。肌肉关节痛，脱发常见。 结论 小剂量紫杉醇（60 mg/m2）联合顺铂（20 mg/m2）方案在宫颈癌根治性化疗中值得推荐。 　　[关键词] 宫颈癌；根治性放疗；紫杉醇；顺铂；小剂量 　　[中图分类号] R737[文献标识码] A[文章编号] 1673-7210（2012）03（c）-0085-02 　　Prospective study of low dose Paclitaxel and Cisplatin for treatment of advanced cervical cancer 　　WANG Wenxiang1FAN Wenqiang2DONG Xuecai1MA Ruixia1CHEN Caixia1 　　1.Department of Gynecology and Gynecology Oncology, the Central Hospital of Xinxiang City, Henan Province, Xinxiang 453000, China; 2.Department of Rheumatology, the Central Hospital of Xinxiang City, Henan Province, Xinxiang 453000, China 　　[Abstract] Objective To compare the efficacy and toxicity of different dose Paclitaxel and Cisplatin for advanced cervical cancer in stage Ⅱa-Ⅲb. Methods 65 patients with advanced cervical cancer were divided into TP1 group and TP2 group. TP1 group: Taxol 60 mg/m2, Cisplatin 20 mg/m2, repart every 8-10 days. TP2 group: Taxol 135 mg/m2, Cisplatin 60 mg/m2, the interval was 21 days. Results ①The overall response rate (CR+PR) was 100%, TP1 group was equivalent of TP2 group; ②TP1 group was less than TP2 group in the average course of treatment period (P ＜ 0.05); ③the major side effects were hematological toxicity and gastroenteric reactions. Thehematological toxicity was more common in TP2 group than TP1 group (P ＜ 0.05). Neurotoxicity and alopecia were similar between two groups. Conclusion Paclitaxel (60mg/m2) plus Cisplatin (20 mg/m2) is worth to be recommended in concurrent chemoradiotheapy for advanced cervical cancer. 　　[Key words] Advanced cervical cancer; Concurrent chemoradiotherapy; Paclitaxel; Cisplatin; Low dose 　　放射治疗为中晚期宫颈癌的主要治疗???段。本研究重在探讨紫杉醇联合顺铂周疗方案在中晚期宫颈癌同步放疗中的疗效、副反应，取得较好的临床疗效。现报道如下： 　　1 资料与方法 　　1.1一般资料 　　选择2009年6