Antibacterial Handwashes with Antimicrobial Persistence：抗菌handwashes抗菌持久性.pptVIP

Antibacterial Handwashes:Formulations with Antimicrobial Persistence Lawton Seal, PhD Sr. Program Manager Healthpoint RD Antibacterial Handwashes Consumer products for hand antisepsis are not routinely formulated to provide antimicrobial persistence or residual effects, allowing for relative rapid re-growth of flora Therefore, frequent product applications are needed to maintain some degree of hand antisepsis Alcohol-based formulations can be produced that provide prolonged antimicrobial action, may be used with or without water, and do not overtly damage the skin Given the importance of this product indication to the general public, we tested to ensure appropriate efficacy Testing Methods Supporting data was obtained employing the following test methods: Tentative Final Monograph in vivo test for Health Care Personnel Handwash (HCPHW) 5-day in vivo persistence assay: Similar concept to surgical scrub test Washout for 7 days and baseline assessments Four daily product applications (in an hour) per product instructions Application times varied Subjects gloved Post-application samples at 1 min, 4 hrs, and 8 hrs Both water-aided and waterless product applications were tested Results published: Am J Infect Control 2005:33:207-216. Waterless ProductsTFM in vivo HCPHW Test Waterless Products5-day in vivo Persistence Test Water-aided Products TFM in vivo HCPHW Test Water-aided Products5-day in vivo Persistence Test Conclusions These data support our assertion that antimicrobial persistence is available to the consumer A TFM-like test should be employed for these consumer products Thus provide adequate information about the level and duration of antimicrobial action * * Am J Infect Control 2005:33:207-216 Am J Infect Control 2005:33:207-216 Am J Infect Control 2005:33:207-216 Am J Infect Control 2005:33:207-216