酒精性肝硬化患者血清脂肪因子的临床意义分析.docVIP

酒精性肝硬化患者血清脂肪因子的临床意义分析 　　[摘要]目的 探?酒精性肝硬化患者血清脂肪因子的临床意义。方法 将2014年3月～2016年3月于河北省沧州市中心医院住院治疗的52例酒精性肝硬化患者作为肝硬化组，其中Child-Pugh分级A级17例，B级20例，C级15例；同时选择32名健康体检者作为对照组。检测并比较肝硬化组及不同Child-Pugh分级的肝硬化患者与对照组的血清网膜素、脂联素、内脏脂肪素及其他相关的临床生化参数；采用Spearman等级相关分析法及线性回归方程分析酒精性肝硬化患者血清脂肪因子与各生化指标的相关性。结果 肝硬化组患者血清网膜素、脂联素水平分别为（925.19±167.58）ng/L和（908.06±156.96）μg/L，明显高于对照组[（793.68±100.38）ng/L、（649.97±105.01）μg/L]（P0.05），而随着Child-Pugh分级A、B、C级的逐渐增高，肝硬化组患者的HOMA-IR和IL-6水平也逐渐升高（P0.05）。结论 肝硬化时网膜素、脂联素升高，内脏脂肪素下降，其可作为预测肝硬化的指标，但不能作为肝功能严重程度的评估指标 [关键词]酒精性肝硬化；网膜素；脂联素；内脏脂肪素；Child-Pugh分级；胰岛素抵抗 [中图分类号] R575.5 [文献标识码] A [文章编号] 1674-4721（2016）11（a）-0018-04 Analysis of clinical significance of serum adipocyte factors of patients with alcoholic cirrhosis WEI Xin-liang WEI Si-chen TIAN Shu-ying KONG Yu WANG Wei-wei JIANG Hong-yu Deparment of Gastroenterlogy，the Central Hospital of Cangzhou City，Hebei Province，Cangzhou 061001，China [Abstract]Objective To investigate the clinical significance of serum adipocyte factors in patients with alcoholic cirrhosis.Methods 52 patients with alcoholic cirrhosis from March 2014 to March 2016 in the Central Hospital of Cangzhou City were selected as liver cirrhosis group，among which 17 cases of class A of Child-Pugh grading，20 patients with class B，15 cases of grade C；and 32 healthy controls were selected as control group at the same time.Levels of serum omentin，adiponectin，visfatin and other related clinical and biochemical parameters were measured and compared between patients with liver cirrhosis，different Child-Pugh class of liver cirrhosis and control group.Spearman rank correlation analysis and equation of linear regression were used to analyzed the relationship between cirrhosis serum fat factors and the related biochemical indicators of patients with alcoholic liver.Results The levels of serum omentin and adiponectin in the liver cirrhosis group [（925.19±167.58） ng/L，（908.06±156.96） μg/L] were significantly higher than those of the control group [（793.68±100.38）