逍遥散对肝纤维化大鼠肝脏保护作用研究.docVIP

逍遥散对肝纤维化大鼠肝脏保护作用研究 　　[摘要] 目的 观察逍遥散对胆管结扎致肝纤维化大鼠肝功能及肝纤维化指标的影响。方法 采用胆管结扎法复制肝纤维化大鼠病理模型，各组大鼠分别以生理盐水、阳性对照药、低剂量逍遥散、高剂量逍遥散进行干预，测定各组大鼠血清ALT、AST、TBIL、HA、PCⅢ、LN、Ⅳ-C水平。结果 肝纤维化模型组大鼠血清ALT、AST、TBIL、HA、PCⅢ、LN、Ⅳ-C水平均显著高于假手术组（P＜0.05）；阳性对照药组、逍遥散高剂量组大鼠血清ALT、AST、TBIL、HA、PCⅢ、LN、Ⅳ-C水平均显著低于肝纤维化模型组（P＜0.05）。结论 逍遥散对胆管结扎致肝纤维化大鼠肝功能具有一定程度的保护作用，对肝纤维化具有一定的防治作用。 　　[关键词] 逍遥散；肝功能；肝纤维化 　　[中图分类号] R285.5 [文献标识码] A [文章编号] 1673-9701（2011）36-27-02 　　 　　Study on Liver Protective Effect of Xiaoyao Powder in Hepatic Fibrosis Rats 　　WANG Youli1 LANG Dehai2 　　1.Shenzhen Health Center of Ninghai Coutry in Zhejiang Province，Ninghai 316514，China；2.Department of Surgeon，Second Hospital of Ningbo City in Zhejiang Province，Ningbo 315010，China 　　 　　[Abstract] Objective To observe the effects of Xiaoyao Powder on the liver function and hepatic fibrosis indexes of the hepatic fibrosis rats induced by common bile duct ligation. Methods The rats models of hepatic fibrosis were made by common bile duct ligation. The rats were divided into five groups: control group，model group，positive drug control group，low dosage Xiaoyao Powder group and high dosage Xiaoyao Powder group，and all groups were treated separately with normol solution，positive drug，low dosage Xiaoyao Powder and high dosage Xiaoyao Powder respectively. Then the content of ATL，AST，TBIL，HA，PCⅢ，LN，Ⅳ-C in serums of rats were detected. Results Compared with control group，the content of ATL，AST，TBIL，HA，PCⅢ，LN，Ⅳ-C in serums of rats of model group all significantly were raised（P＜0.05）. Compared with model group，the content of ATL，AST，TBIL，HA，PCⅢ，LN，Ⅳ-C in serums of rats of positive drug control group and high dosage Xiaoyao Powder group significantly were reduced（P＜0.05）. Conclusion Xiaoyao Powder has some influences on the protection of liver and has the effect on anti-hepatic fibrosis. 　　[Key words] Xiaoyao Powder；Liver function；Hepatic fibrosis 　　肝纤维化（hepatic fibrosis，HF）是慢性肝病重要的病理特征，患者肝脏内纤维组织异常增生，是肝硬化的早期病理基础和必经中间环节[1]。本研究采用胆管结扎法复制大鼠肝纤维化病理模型，探讨逍遥散对肝纤维化大鼠