甲流H1N1精品课件Pandemic Influenza A （H1N1） Virology .pptVIP

BEGINNING OF THE 2009 H1N1 PANDEMIC HOST AND LINEAGE ORIGINS FOR THE GENE SEGMENTS OF THE 2009 A(H1N1) VIRUS REASSORTANT EVENTS AMONG SWINE INFLUENZA VIRUSES (SIV)IN NORTH AMERICA ORIGIN OF THE 2009 PANDEMIC H1N1 VIRUS Evolutionary Relationships Among 2009 Pandemic Influenza A (H1N1) Hemagglutinin (HA) Genes Evolutionary Relationships Among 2009 Pandemic Influenza A (H1N1) Neuraminidase Genes GENETIC DISTANCE BETWEEN A/NEW JERSEY/8/1976 AND A/TEXAS/05/2009COMPARING WITH H3N2 VIRUSES HI REACTIONS OF PANDEMIC INFLUENZA H1N1v VIRUSES (CDC) HI REACTIONS OF PANDEMIC INFLUENZA H1N1v VIRUSES (NIMR) HI REACTIONS OF PANDEMIC INFLUENZA H1N1v VIRUSES (NIID) COUNTRIES FOR WHICH SEQUENCING OR ANTIGENIC DATA ARE AVAILABLE RESISTANCE OF PANDEMIC INFLUENZA H1N1v VIRUSES TOADAMANTANES (M2 BLOCKERS) RESISTANCE OF PANDEMIC INFLUENZA H1N1v VIRUSES TONEURAMINIDASE INHIBITORS SERUM CROSS-REACTIVE ANTIBODY RESPONSE TO A NOVEL INFLUENZA A(H1N1) VIRUS AFTER VACCINATION WITH SEASONAL INFLUENZA VACCINES (MMWR MAY 2009) SERUM CROSS-REACTIVE ANTIBODY RESPONSE TO A NOVEL INFLUENZA A(H1N1) VIRUS AFTER VACCINATION WITH SEASONAL INFLUENZA VACCINES (MMWR MAY 2009) IMMUNITY TO 2009 H1N1 VIRUS RESULTING FROM PRIOR INFLUENZA INFECTION OR VACCINATION WITH SEASONAL INFLUENZA VACCINE IN DIFFERENT AGE GROUPS (NEJM submitted) Less than 4% of individuals born during or after 1980 exhibited preexisting, cross-reactive, neutralizing antibody titers of ≥40 to the pandemic virus, whereas 34% of individuals born prior to 1950 had titers of ≥80 Vaccination with recent seasonal trivalent influenza vaccines (TIV), resulted in a 4-fold rises in cross-reactive antibody to the pandemic virus in only ~2% of children aged 6 months to 9 years, 12-22% of adults aged 18-64 years, and 5% or less of adults aged 60 years Seasonal TIV with adjuvant induced similar cross-reactive antibody responses; no increase in cross-reacting antibody to pandemic H1N1 virus CONCLUSIONS All 2009 pandemic H1N1 viruses