艾滋病的防治研究生课件.pptVIP

* * How ZDV decreases vertical transmission is fully determined, but at least part of its benefit is likely due to a post-exposure prophylaxis effect. Data for AZT in pregnancy is very reassuring No increased incidence of congenital abnormalities, preterm delivery, low birthweight No differences in immunological, neurodevelopmental and growth variables at 6 years follow up No increase in neoplastic disease at 6 year follow up -Some nucleoside analogue agents are carcinogenic in rodents and can induce mitochondrial dysfunction in vitro -Reversible mitochondrial dysfunction has been reported