2010肾上腺素能药物及局麻药.pptVIP

Adrenoceptor agonists and antagonists and local anesthetics Adrenoceptor agonists Basic actions: Excitation of smooth muscles (skin vessel and mucosal vessel) Inhibition of smooth muscles (intestine, bronchia and skeletal muscle vessel) Excitation of heart Metabolism (glycogenolysis and lipolysis) Endocrine effects (insulin↓, renin↑, etc.) CNS excitatory effects epinephrine 1, cardiovascular system Heart（β1）: HR↑, contraction↑, conductance↑, cardiac output↑, oxygen consumption↑ arrhythmia (large dose) Blood vessel（? receptors）: contraction in skin, mucus, abdominal viscera