与急性粒细胞白血病.pptVIP

Case: Follow-up BM (%) 0 20 40 60 80 100 Day 0 Day 15 Day 30 Day 75 LD cycle 1 BM blasts BM cellularity WBC count Hemoglobin (g/dL) 0 2 4 6 8 10 12 Day 0 Day 15 Day 30 Day 75 LD cycle 1 Hemoglobin Platelets 0 2.0 4.0 6.0 8.0 10.0 0 50 100 200 250 300 Platelets (x103/?L) WBC (x 103/?L) 150 CR Aspirate 100X CR Leder 10X CR Leder 100X Lenalidomide: Mechanism? N N H O O O N H 2 Block Angiogenesis Direct Effects on tumor Alter cytokine profiles Immune modulation Phosphatase modulation Lenalidomide (Revlimid) Multiple Myeloma Lymphoma MDS (w/ 5q-) Activity Potential Mechanism(s) CLL AML Lenalidomide