协和医学院病理呼吸系统课件PPT.ppt

* Complications of bronchopneumonia Lung abscesses Empyema Suppurative pericarditis Bacteremia with metastatic abscess formation in other organs and tissue in the body * Legionella pneumonia An outbreak of severe pneumonia affected 180 of about 4400 persons attending the Annual Convention of American Legionnaires in Philadolphia,USA during July 1976, causing 29 deathes. Gram (-) fibrinopurulent bronchopneumonia abundant fibrin, variable macrophage and neutrophils * Atypical pneumonia Usualy absence of physical findings of consolidation and only moderate elevation of white cell count A pulmonary inflammatory large confined to alveolar septa and pulmonary interstitium, Lack of alveolar exudate(interstitial pneumonia) Commonly caused by mycoplasma,viruses… mycoplasma pneumonia viral pneumonias * Histologically:the inflammatory reactionis largely confined within the wall of the alveoli. * Clinically, respiratory distress seemingly out of proportion to the physical and radiographic findings * Severe acute respiratroy syndrome(SARS) Coronavirus (SARS-CoV) Infect the lower respiratory tract and induce viremia The histopathology of lung of SARS usually demonstrated Diffuse alveolar damage Pneumocystis（卡氏肺孢菌） pneumonia P.carinii An opportunistic infections occurred in immunocompromised person AIDS Organ transplantation chemotherapy malnourished children * Pulmonary tuberculosis a chronic granulomatous disease caused by M. tuberculosis, usually affecting the lungs, but virtually any extra-pulmonary organ can be involved by isolated tuberculosis. * Characteristic tubercle –-----  tuberculous granuloma（即结核结节tubercle） Central caseous necrosis以及四种细胞成分 epithelioid cells Multinucleated giant cells Lymphocytes Fibroblastic cell * Primary pulmonary tuberculosis Children The form of disease that develops in a previously unexposed ,unsensitized person It begins as a single granulo