cmi2014chapter3inducedinnateimmunity1ppt课件.pptVIP

思考题 固有免疫系统如何通过不同的PRR识别不同亚细胞部位的病原体感染？ 诱导性固有免疫反应的主要效应机制有哪些？ 简述炎症小体的激活通路。 The end of chapter 3 NALP3 (NLRP3) and Gout (痛风) The disease gout has been known for many years to be caused by monosodium urate (尿酸钠) crystals deposited in the cartilaginous tissues of joints, causing inflammation. Urate crystals (尿酸钠晶体) activate the NALP3 inflammasome, and that this induces the inflammatory cytokines that cause the symptoms of gout. Pattern recognition by cells of the innate immune system. 3-9 The RIG-I-Iike helicases (解旋酶) detect cytoplasmic viral RNAs and stimulate interferon production.