离子通道受体-教学课件.pptVIP

Subclass 1. Cys-loop ion-channel receptors 2Cys环配体门控离子通道 N型ACh受体 结构 五聚体：两个a，一个b，一个g，一个d。单个亚基：四个疏水片段M1，M2，M3，M4 Synaptic Transmission Excitory Post- Synaptic Potential EPSP Inhibitory Post- Synaptic Potential IPSP 谷氨酸离子通道受体Glutamate receptors Glu R NMDA R N-methyl-D-aspartate R 甲基门冬氨酸受体 AMPA R Amino-3-hydroxy-5-methylisoxazole-4-propionic acid R 使君子酸受体 Kainate R 红藻酸受体 Na+ and Ca2+ inward, K+ outward Structure: Each receptor is a hetero-oligomer of 5 subnunits Each subunit is composed of three TMS and one reentrant loop AMPA R: GluR1 ~ GluR4 KA R: GluR5 ~ GluR7, KA1 and KA2 NMDA