111生物化学理论课件@中科大3DNARNA12008PPT.ppt

4. Plasticity of Secondary and Tertiary DNA Structure Levels of DNA structure Primary structure: sequence of nucleotides Secondary structure: path of strands double helix Tertiary structure: path helix takes in space supercoiling 2m of DNA, all 3 billion letters in the DNA code, compacted into 46 chromosomes, and packed into a cell 0.0001cm across! DNA CHROMOSOMES 4.1 Changes in Tertiary Structure: Supercoiling 超螺旋 topology Twist (T)扭转数 Writhe (W) 缠绕数 Linking number (L)连环数 L = T + W relaxed supercoiled Telephone cord Twist扭转数 ------ the total number of times the