15-超敏反应研课程2015PPT.pptx

超敏反应?Hypersensitivity 超敏反应 是指机体接触某些抗原致敏后，再次受到相同抗原刺激时表现出的增高的敏感性或增强的反应性，出现以生理功能紊乱或组织细胞损伤为主的异常的特异性免疫应答。 超敏反应的分型 Coombs和Gell根据超敏反应机制和临床特点，将超敏反应分为四种类型。 Penicillin-induced hypersensitive reaction参见表15-1Immunological hypersensitivity reactions, or allergic reactions, are mediated by immune reactions that cause tissue damage. Four types of allergic reaction are generally recognized. Types I-III are antibody-mediated and are distinguished by the different types of antigen recognized and the different classes of antibody involved. Type I responses are mediated by lgE, which induces mast-cell activation