免疫球蛋白(Ig)PPT.pptVIP

Isotypes definition Antigenic determinants that characterize the classes and subclasses of heavy chains and types and subtypes of light chains location IgM (kappa) IgG1 (kappa) 同一种属所有个体的Ig分子均具有的抗原特异性。主要存在于Ig的C区。 Allotypes definition Antigenic determinants specified by allelic forms of the Ig genes location IgG1 (kappa) Person 2 IgG1 (kappa) Person 1 同一种属不同个体间的Ig分子所具有的不同的抗原特异性。主要存在于重链和轻链的稳定区，实际上可作为一种遗传标志。 Idiotype definition Unique antigenic determinants present on individual antibody molecules . location Ag1 epitope1 Ab1 Ab2 Ab3 同一个体不同Ig的抗原特异性，主要存在于Ig 的CDR区。 Ⅲ. FUNCTIONS OF ANTIBODY 抗体的功能 Ⅰ Ⅰ VH CH1 CH2 CH3 CH4 VL CL Fab Fc COO– NH3+ C region: 1、fixation of complement 2、binding cells opsonization mediating ADCC mediateing Hypersensitivity I 3.crossing the placenta mucosal tissues V region: Ag binding Neutralizing toxin virus Agglutination microbes, Prevention adhesion VH CH1 CH2 CH3 CH4 VL CL Fab Fc COO– NH3+ C region: 1、激活补体 2、Fc段结合到细胞表面 调理作用 介导 ADCC 介导 Hypersensitivity I 3. 穿过胎盘与粘膜组织 V region: 结合抗原 中和毒素和病毒 凝集作用 Neutralizing toxin virus Agglutination microbes Activation Complement C1r C1s C1q C1r C1s C1q No activation Activation C1qr2s2 opsonization O P S O N I Z A T ion Fc?R antibody-dependent cell-mediated cytotoxicity Target cell Ab Effector cell Target cell A form of nonspecific cytotoxic cell-mediated reaction in which an Effector kills an antibody-coated target cell,presumably by recognition of the Fc region of the cell-bound antibody through an Fc receptor presented on the effector cell (e.g., NK cells, neutrophils,Macrophages). ADCC mediating Hypersensitivity I crossing the placenta mucosal tissues C s T Ⅳ. Properties Biological Activities of Five Classes of Immunoglobulins 五类Ig的特性与功能 Ⅰ Ⅰ IgG 1. IgG1, IgG2 and IgG4 IgG3 Four Subclasses of Human IgG structure General structure of the four subclasses of human IgG, which differ in the number a