可逆热固性原位胶凝流特性的解决方案与甲基纤维素聚乙二醇柠檬酸三元系统毕业论文外文翻译.docVIP

可逆热固性原位胶凝流变特性的解决方案与甲基纤维素聚乙二醇柠檬酸三元系统 Masanobu Takeuchi Shinji Kageyama Hidekazu Suzuki Takahiro著，…..译. [摘要] 可逆性溶胶凝胶温度的转变受到甲基纤维素(MC)、聚乙二醇(PEG)、柠檬酸(SC) 三元体系的影响，通过流变学测量得出原位凝胶体系的性能。当PEG（4000）的浓度在0%到10%范围内变化，MC（25）和SC浓度分别保持在1.5%和3.5%时，随着PEG浓度的增加，可逆性溶胶转变温度从38°C降低至26°C，然而，温度降低的程度不受PEG分子量的影响，随着MC浓度的增加可逆溶胶~凝胶的温度降低，同时随着ph值的降低可逆溶胶~凝胶的温度升高，在流变特性的比较方面，目前原位胶凝的设置解决方案和常规相比，如结冷胶溶液或泊洛沙姆407,显示目前的解决方案从根本上有别于传统的解决方案，这些研究结果表明，这项研究中的三元体系可作为在眼部传递灌输系统的药物。 [关键词] 热定形凝胶 ；溶胶凝胶转变温度；甲基纤维素聚乙二醇柠檬酸三元体系 1 前言 2 实验材料 2.1 原位凝胶溶液的制备 2.2 泊洛沙姆溶液的制备 2.3 胶凝温度通过试管倒置法测量 3 结果与讨论 3.1 PEG对可逆溶胶凝胶转变温度的影响 图1 图1 温度对热定形凝胶溶液的表观粘度的影响。聚乙二醇浓度：0 %，2 %，4 %，6 %，8 %，10 %。表观粘度测定用流变仪测定。甲基纤维素（SM 25）和柠檬酸钠二水合物的浓度分别恒定保持在1.5%和3.5%，而聚乙二醇（PEG 4000）的浓度变化范围在0%到10% 图2试管反演方法和流变仪测量法，图中x和y分别表示用试管倒置法测量的相转变温度和用流变仪测量的相转变温度，甲基纤维素(SM 25)和柠檬酸钠二水物浓度分别保持恒定在2 %和3.5%，聚乙二醇（PEG 4000）的浓度变化范围在0%到10%之间。 4 结论 参考文献 Rheological properties of reversible thermo-setting in situ gelling solutions with the methylcellulose–polyethylene glycol–citric acid ternary system Masanobu Takeuchi Shinji Kageyama Hidekazu Suzuki Takahiro Wada Yoshitada Notsu Fumiyoshi Ishii Abstract The composition of vehicle on the reversible sol–gel transition temperature in a ternary system made up of methylcellulose (MC), polyethylene glycol (PEG), and citric acid (SC) was investigated. The properties of the in situ gelling system were estimated by rheological measurement. When PEG (4000) concentration was varied from 0% to 10% while MC (SM25) and SC concentrations were kept constant at 1.5% and 3.5%, respectively, the reversible sol–gel transition temperature lowered from 38 _C to 26 _C with increasing PEG concentration. However, the extent of lowering in temperature was not influenced by the molecular weight of PEG. The reversible sol–gel transition temperature shifted towards the lower temperature with increasing MC concentration, and towards the higher temperature with decreasing pH. Comparison of rheological properties between the present thermo-setting in situ gelling solution and a