国外高分子科学与工程教材与参考的资料96313.pdfVIP

Chapter 13 FUNCTIONAL HYDROPHILIC-HYDROPHOBIC HYDROGELS DERIVED FROM CONDENSATION OF POLYCAPROLACTONE DIOL AND POLY(ETHYLENE GLYCOL) WITH ITACONIC ANHYDRIDE Monica Ramos and Samuel J. Huang Institue of Materials Science and Department of Chemistry, University of Connecticut, 97 North Eagleville Road, Storrs, CT, 06269. 1. INTRODUCTION Among some of the most important biorelated polymers are PCL, and poly(ethylene glycol), PEG. PCL, a fully biodegradable semi-crystalline polymer, has been used widely in the production of burn covers, elastomeric fibers, paints, and thermoplastics.[l-3] PEG, a water-soluble polymer, has been used extensively in the toiletry and cosmetic industry. Biomaterials based on polyethylene oxide (PEO), both crosslinked and linear, have shown low immunogenicity, reduced thrombogenicity and reduced protein and cell adherence. [4-7] Water-containing gels derived from these biopolymers have been the subject of many studies in the field, as they are known to have low interfacial tension with the surrounding biological environment. While they are insoluble in water, their hydrophilicity enables them to swell in water without losing their structure. As a result, these polymers are able to mimic hydrated- based materials in the body. These gels have been used in prosthetic materials, soft lenses, catheters, membranes, and as bioactive releasing agents. [8-11] Moreover, they show promise in molecular imprinting as antibody- and receptor site-mimicking systems, shape memory devices, or enzyme-mimicking catalytic systems. [12] 185 186 RAMOS AND HUANG Smart gels are known to have the ability to change