中国医科大学七年制遗传重点..docxVIP

98期七年制《Human Development and Genetics》made by 98k73b题型：1. 单选题 20题，每题1分，共20题单项选择题（只有一个答案），比较简单2. 填空题20空，每空0.5分，共10分E.g.非整倍体形成的原因________, ________遗传异质性包括________、多基因病的几条需要背会一级亲属发病率计算从ppt上找原话填空3. 概念题10题，每题2分，共20分每章重点单体型的概念4. 简答题4题，每题5分，共20分基因治疗的策略、Lyon假说的5. 综合分析题3题，每题6、6、8分，共20分e.g. 间接基因诊断的方法（pku\血友病）、系谱分析（给描述画图\给系谱让你分析）（分析遗传类型、为什么是这种遗传类型、写基因型、算发病率、）用所学过的知识解释某个现象，镰状细胞贫血，设计实验方案找出变异，甲和乙都是聋哑但后代没有解释为什么，肿瘤二次突变（视网膜母细胞瘤为什么又遗传性和非遗传型），结肠息肉到结肠癌（多阶段多步骤））6. 整合分析题1题，每题10分，共10分染色体病——遗传学、生殖内分泌、胚胎发育三个角度解释这种症状Chapter 1 头两个很重要Definition: medical genetics, genetic disorder医学遗传学（概率大）遗传病Characteristics and classification of genetic disorders分几类每一类要能写出几种病Landmarks in medical genetics选择题知道名字比较重要的Aim of Human Genome Project填空题基因组测序的两种技术的名字Two genome-sequencing strategiesImportant events in HGPChina Contribution to HGPChapter2 第一页ppt考点多Definition: gene, genome, gene family, pseudogene, split gene, GT-AG rule, flanking sequence, cis-acting element, trans-acting element, mutation, frameshift mutation, dynamic mutation, probe, recombinant DNA, vector, DNA libraryClassification of chromatinX-chromatin and Y-chromatine.g.XY都在哪内缘、里面怎么检测几个X几个Y X兼性异染色质（易考X）Regulation mechanism of epigeneticsChapter 2 第二页pptNuclear genome and mitochondrial genome Basic structure of DNA and its biological significanceClassification of repetitive sequenceCharacteristic of eukaryotic structural geneRNA processingTypes of gene mutationMethods of probe labelingSouthern Blotting, Northern Blotting, ASO真核生物结构基因的特点（简答）DNA结构特征和生物学意义（简答）基因突变的类型探针标记有一年考过简答方法Southern等技术考名字Chapter2 第三页pptRestriction endonuclease: nomenclature, recognition sequence, restriction fragmentsCharacteristic of vector and common cloning vectorFour essential steps of cell-based DNA cloningMain types of DNA libraryPCR: principle, steps, reaction system, application, advantage and disadvantagePrinciple of Sanger sequencing载体片段的长度谁大谁小大的用谁小的用谁细胞DNA克隆四步选择题考顺序DNA文库的主要类型基因组文库和cDNA 文库PCR是给案例考方法测序的原理Chapter3Definition: meiosis, Homologous chromosome, SynapsisGenet