PPARγ与MMP9在妊娠期高血压疾病患者胎盘组织的表达及其临床意义.docVIP

PPARγ和MMP9在妊娠期高血压疾病患者胎盘组织的表达及其临床意义 （作者:___________单位: ___________邮编: ___________） 【摘要】 目的 探讨PPARγ和MMP9在妊娠期高血压疾病(HDCP)发生发展中的表达及其临床意义。方法 利用免疫组化SP法检测正常妊娠者31例(对照组)和HDCP患者36例(实验组)胎盘组织中PPARγ、MMP9表达,探讨其与HDCP的关系。结果 ①PPARγ在实验组胎盘组织中明显高表达, 与对照组比较有显著差异(P0.05), PPARγ阳性表达率随病情加重而显著增高。②MMP9在实验组胎盘组织中呈低表达, 与对照组比较有显著差异(P0.05)，MMP9阳性表达率随病情加重而显著降低。③PPARγ与MMP9的Pearman相关分析显示二者表达水平呈负相关(r=-0.529，P0.01)。结论 PPARγ在HDCP患者胎盘中呈高表达，MMP9在HDCP患者胎盘中呈低表达, 提示其可能通过抑制滋养细胞的浸润能力而参与HDCP的发病。 【关键词】 过氧化物酶体增殖物激活受体γ;基质金属蛋白酶9;妊娠期高血压疾病;胎盘;免疫组化 　　ABSTRACT: Objective To investigate the expressions and clinical significance of PPARγ and MMP9 in the genesis and development of hypertensive disordercomplicating pregnancy (HDCP). Methods The expressions of PPARγ and MMP9 in placenta of 31 normal pregnant women (control group) and 36 pregnant women with hypertensive disordercomplicating pregnancy (experimental group) were detected by using SP method of immunohistochemistry, and the relationship between PPARγ and MMP9 expressions and hypertensive disordercomplicating pregnancy was explored. Results ① PPARγ expression in placental tissues was significantly higher in the experimental group than in the control group (P0.05); PPARγ with positive expression rate of exacerbations was significantly increased. ② MMP9 expression in placental tissues showed low expression in the experimental group, which was significantly different from that in the control group (P0.05); MMP9 with positive expression rate of exacerbations was significantly decreased. ③ The Pearman correlation analysis of PPARγ and MMP9 showed that the expression level of the two had a negative correlation (r=-0.529, P0.01). Conclusion PPARγ has a high expression in the placenta of patients with HDCP while MMP9 has a low expression, suggesting that they may be involved in the pathogenesis of HDCP by inhibiting the infiltration capacity of nourishing cells. 　　KEY WORDS: peroxisome proliferationactivated receptor γ(PPARγ); matrix metallopro