Gildas_Club （上海交大仁济临床医学院《医学专业英语》课件PPT）.ppt

Making babies: Genetically Correct Zhi Hua Ran The department of Gastroenterology Ren Ji Hospital A Glossary of Genetics Terms A Glossary of Genetics Terms A Glossary of Genetics Terms A Glossary of Genetics Terms Milestones of Genetics Discover the DNA structure 1953---James Watson/Francis Crick Biography---James Watson Biography---James Watson Biography---James Watson Biography---James Watson Biography---Francis Crick Biography---Francis Crick Biography---Paul Berg The Human Genome Project The Human Genome Project The Human Genome Project---more powerful tools In Vitro Fertilization---history In Vitro Fertilization In Vitro Fertilization In Vitro Fertilization ICSI---Intracytoplasmic sperm injection In Vitro Fertilization Thumbing through the encyclopedia of life Prenatal Genetic Analysis Prenatal Genetic Analysis Prenatal Genetic Analysis Prenatal Genetic Analysis Novel parameters for prenatal selection--- gene testing Gene testing---HD Gene testing---SMA Gene testing--- Fanconi Syndrome Pre-implantation diagnosis Technology --- RT-PCR Gene therapy Dr. Mark Hughes We can test for lots of things, the question is, should we? Huntington‘s disease (HD): Usually midlife onset; progressive, lethal, degenerative neurological disease Caused by a single abnormal gene An autosomal dominant disorder One of the neuromuscular diseases. Muscles weaken and waste away (atrophy) due to degeneration of motor neurones which are nerve cells in the spinal cord Gene was located Proximal portion of the long arm of chromosome 5 , 1990 A disorder in which the proximal renal tubules of the kidney do not properly reabsorb electrolytes and nutrients back into the body Excessive drinking, urination and glucose in the urine Muscle wasting, acidosis and poor condition will also occur Single cell analysis Technology: RT-PCR Electrophoresis DNA microarray A normal gene may be inserted into a nonspecific location within the genome to replace a non