Plasma Potassium Increase after Collaboration Support Offie 血浆钾增加后的协作支持办公室.docVIP

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Plasma Potassium Increase after Collaboration Support Offie 血浆钾增加后的协作支持办公室.doc

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Plasma Potassium Increase after Collaboration Support Offie 血浆钾增加后的协作支持办公室

Plasma Potassium Increase after Cardiac Arrest at Hypothermia and at Normothermia Med student Louise Kollander JakobsenLtCol Med Ass. Prof. Benedict KjaergaardSurg Cdr Ass. Prof. Peter Juel Thiis Knudsen Center for Cardiovascular Research Aarhus University Hospital in Aalborg, Denmark Hobrovej 18-22, DK-9100 Aalborg and Institute of Forensic Medicine University of Southern Denmark DK-5000 Odense Denmark l_kollander@ / benedict@dadlnet.dk Abstract Background: The purpose of this study was to get information on how potassium rises in blood plasma after cardiac arrest at low core temperature versus after cardiac arrest at a normal core temperature. Potassium can be used as a marker of cell autolysis and therefore a measure of how far the body is in the dying process. An accidental hypothermic victim may appear dead but normally accepted signs of dead such as rigor or lividity are unreliable. But when plasma potassium raises above10 mmol/l it has never been possible to resuscitate an apparently dead hypothermic person. Even though we know that survival is impossible with higher levels of potassium, a lower level is not a guarantee for survival even with our best guidelines for treatment but little is known about the time for potassium to rise to this level in the cold versus in the warm person. Methods: Five anesthetized pigs were attached to extracorporeal circulation (ECC) using percutaneous access to the femoral vessels and cooled to 20 oC. The ECC was interrupted and the tracheal tube was blocked where after the pigs developed circulatory arrest. After cardiac arrest we took blood samples from an arterial sheat every 15 minutes. This was possible because the pigs were treated with heparin and because the pigs had external cardiac compressions using a LUCAS device in 30 seconds just before blood samples were taken the. In this way the lifeless pigs had blood pressure enough to supply us with arterial blood from the body core. Another 5 pigs served as a control gro