地塞米松对氟比洛芬超前镇痛的影响.docVIP

地塞米松对氟比洛芬酯超前镇痛的影响 冯翠* 王颖 李军 戚思华 高大鹏 韩宝庆 【摘要】 目的 探讨地塞米松复合氟比洛芬酯超前镇痛对术后疼痛的影响。方法 33例择期妇产科手术，随即双盲分成地塞米松10mg复合氟比洛芬酯100mg/kg组（Ⅰ组）、氟比洛芬酯组100mg（Ⅱ组）、芬太尼50μg复合氟比洛芬酯组100mg（Ⅲ组）。所有患者均接受L2～3腰-硬联合阻滞。所有药物按分组于手术结束前15min一次性静脉注入，观察术后6h、12h、24h、48h及72h的VAS评分、Ramsay镇静评分及不良反应。结果 术后各个时点，Ⅰ组的VAS评分都低于Ⅱ组和Ⅲ组（P＜0.05）；Ⅰ组术后24h的VAS评分高于其他各个时点（P＜0.05）VAS评分低于24h（P＜0.05）。三组之间Ramsay评分无差别 (P＞0.05)。Ⅱ组和Ⅲ组追加镇痛药的次数高于Ⅰ组（P＜0.05）。Ⅲ组恶心及皮肤瘙痒的发生率高于Ⅰ组和Ⅱ组（P＜0.05）。结论 地塞米松可以协同氟比洛芬酯超前镇痛作用，延长术后镇痛时间，副作用小，是良好的超前镇痛方法。 【关键词】 地塞米松 氟比洛芬酯 芬太尼 超前镇痛 静脉 Effect of dexamethasone on preemptive analgesia of flurbiprofen axetil FENG Cui, WANG Ying, LI Jun, et al. Department of Anesthesiology, fourth Affiliated Hospital, Harbin Medical University, Harbin 150001, China 【Abstract】 Objective To investigate preemptive analgesia effect of dexamethasone combined with flurbiprofen axetil on postoperative pain. Methods Thirty-three patients undergoing selective gynecological and obstetric operation were randomly divided into three groups: （）dexamethasonemg combined with flurbiprofen axetil 100mg;（） flurbiprofen axetil 1mg; （） fentanylμg combined with flurbiprofen axetil 100mg. All patients were to receive L2-3 puncture for subarachnoid block combined epidural anesthesia.All medicine in every group were infused intravenously before 15min of the operation was ended. Visual analgesia scale(VAS)、Rasmay scale and side effects were recorded at 6h,12h,24h,48h and 72h after operation. Results VAS in groupⅠwere lower than those in group Ⅱand Ⅲ at each time point(P＜0.05)VAS in groupⅠat 24 hours were higher than all other time points (P＜0.05) VAS in groupⅡand Ⅲ at 48、72 hours were lower than those at 24 hours (P＜0.05)Ramsay scores between groups (P＞0.05). The numbers of additional analgesics in groupⅡand Ⅲ were higher than those in groupⅠ(P＜0.05). Tincidence of nausea and skin itching in group Ⅲ were higher than those in groupⅠand Ⅱ（P＜0.05).Conclusion Dexamethasone may have synergistic preemptive analgesia effect when combined with flurbi